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            What is SCB?

            SCB, is an advanced system to detect the sensitivity and resistance of tumor cells against chemotherapeutic drugs or regimens. SCB assists doctors in optimizing chemotherapy regimens and unnecessary pain of patients would be relieved. SCB utilizes the advanced microfluidic single cell technology from Canada to separate and fix single tumor cell. But also it is able to simulate the human body microenvironment to avoid interferential factors of other normal cells. SCB has competence to provide accurate detection reports to doctors.





            Multidrug Resistance (MDR)

            The tumor cells,  with multidrug resistance have low sensitivity to the chemotherapy drugs, are difficult to be eliminated. This is the most critical reason that leads to chemotherapy failure. Therefore, detection of drug resistance and sensitivity of tumor cells before chemotherapy provides a prerequisite for precision medical treatment.






            SCB Provides a Solution to Precision Medicine 






            SCB Cutting-Edge Technology Advantages


            • Single Cell Analysis Technology


            Single cell analysis can accurately reflect tumor cells heterogeneity. Cells response data and information can be monitored in real time for drug delivery at the single cell level. 


            • Microfluidics Technology


            Microfluidic technology is able to simulate human physiological microenvironment, especially for detection of tumor cells activities and drug resistance features. 



            • SCB Patent


            The SCB technology has registered the patent in the United States, Canada, and China.



            Legend-Global Research and Development Department




            參考文獻:
            1. Khamenehfar, A., Beischlag, T. V., Russell, P. J., Ling, M. T. P., Nelson, C., & Li, P. C. H. (2015). Label-free isolation of a prostate cancer cell among blood cells and the single-cell measurement of drug accumulation using an integrated microfluidic chip. Biomicrofluidics, 9(6), 064104.
            2. Khamenehfar, A., Gandhi, M. K., Chen, Y., Hogge, D. E., & Li, P. C. (2016). Dielectrophoretic microfluidic chip enables single-cell measurements for multidrug resistance in heterogeneous acute myeloid leukemia patient samples. Analytical chemistry, 88(11), 5680-5688.
            3. Hee Choi, Y., & Yu, A. M. (2014). ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development. Current pharmaceutical design, 20(5), 793-807.
            4. Gameiro, M., Silva, R., Rocha-Pereira, C., Carmo, H., Carvalho, F., Bastos, M. D. L., & Remi?o, F. (2017). Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP. Molecules, 22(4), 600.
            5. Schinkel, A. H., & Jonker, J. W. (2003). Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Advanced drug delivery reviews, 55(1), 3-29.
            6. Liu, W., Li, L., Wang, X., Ren, L., Wang, X., Wang, J., Tu, Q., Huang, X. and Wang, J., 2010. An integrated microfluidic system for studying cell-microenvironmental interactions versatilely and dynamically. Lab on a Chip, 10(13), pp.1717-1724.









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